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Effect of spaceflight on periosteal bone formation in ratsMale Wistar rats were placed in orbit for 18.5 days aboard the Soviet COSMOS 1129 biological satellite. Tetracycline was administered before and after spaceflight to label areas of bone formation. An inhibition of periosteal bone formation occurred during spaceflight in the tibial and humeral diaphyses, but this defect was corrected during the postflight period. The increased extent of arrest lines at these skeletal sites suggested that periosteal bone formation may have even ceased during spaceflight. The rib exhibited a small but nonsignificant decrease in periosteal bone formation. Endosteal bone resorption was not affected markedly by spaceflight conditions. The observed inhibition of periosteal bone formation may be a result of mechanical unloading, but endocrine factors cannot be ruled out.
Document ID
19830056032
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wronski, T. J.
(NASA Ames Research Center Moffett Field, CA, United States)
Morey, E. R.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
Publication: American Journal of Physiology
Volume: 244
ISSN: 0002-9513
Subject Category
Life Sciences (General)
Accession Number
83A37250
Distribution Limits
Public
Copyright
Other

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