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Cataractogenesis from high-LET radiation and the Casarett modelThe long-term effects on specific animal tissues of exposure to heavy ion irradiation are studied in experiments on cataractogenesis in mice and rabbits. Five groups of rabbits at ages from 8 weeks to 5.3 years were irradiated to a dose of 9.0 Gy of Bragg plateau Ne-20 ions, while mice were exposed to single and total fractionated doses of 4.17 Gy gamma rays or 0.40 to 1.20 Gy of C-12, Ne-20 or Ar-40 particles. Measurements of lens opacities over time show that in the year since irradiation, cataractogenesis is delayed and less severe in rabbits irradiated at age 6 months compared to younger animals, although it is possible that the late effects in adults will surpass those found in the young. The fractionation of the total dose of gamma rays in mice is observed to lead to a marked reduction in the extent of lens opacity after one year, while fractionated heavy ion doses caused a greater degree of posterior lens opacification. Evaluations of the effects of the LET of different ions on cataractogenesis are consistent with RBEs of about 5, 3 and 1-2 for Ar-40, Ne-20 and C-12 ions, respectively. Results thus support the Casarett model of radiation damaging stem cell populations that are not necessarily part of the vasculature.
Document ID
19830059630
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Cox, A. B.
(Colorado State Univ. Fort Collins, CO, United States)
Lee, A. C.
(Colorado State Univ. Fort Collins, CO, United States)
Lett, J. T.
(Colorado State University Fort Collins, CO, United States)
Ainsworth, E. J.
(Colorado State Univ. Fort Collins, CO, United States)
Jose, J. G.
(California University Berkeley, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
83A40848
Funding Number(s)
CONTRACT_GRANT: NIH-AG-0005
CONTRACT_GRANT: NASA ORDER T-3516-G
CONTRACT_GRANT: W-7405-ENG-48
CONTRACT_GRANT: NAG9-10
CONTRACT_GRANT: NSG-9045
CONTRACT_GRANT: DOE-31-109-38-4992
Distribution Limits
Public
Copyright
Other

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