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Tibial changes in experimental disuse osteoporosis in the monkeyThe mechanical properties and structural changes in the monkey tibia with disuse osteoporosis and during subsequent recovery are investigated. Bone mending stiffness is evaluated in relation to microscopic changes in cortical bone and Norland bone mineral analysis. Restraint in the semireclined position is found to produce regional losses of bone most obviously in the anterior-proximal tibiae. After six months of restraint, the greatest losses of bone mineral in the proximal tibiae range from 23 percent to 31 percent; the largest changes in bone stiffness range from 36 percent to 40 percent. Approximately eight and one-half months of recovery are required to restore the normal bending properties. Even after 15 months of recovery, however, the bone mineral content does not necessarily return to normal levels. Histologically, resorption cavities in cortical bone are seen within one month of restraint; by two and one-half months of restraint there are large resorption cavities subperiosteally, endosteally, and intracortically. After 15 months of recovery, the cortex consists mainly of first-generation haversian systems. After 40 months, the cortex appears normal, with numerous secondary and tertiary generations of haversian systems.
Document ID
19830060641
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Young, D. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Niklowitz, W. J.
(NASA Ames Research Center Moffett Field, CA, United States)
Steele, C. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Calcified Tissue International
Volume: 35
ISSN: 0008-0594
Subject Category
Life Sciences (General)
Accession Number
83A41859
Distribution Limits
Public
Copyright
Other

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