NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Antioxidants, metabolic rate and aging in DrosophilaThe metabolic rate-of-living theory of aging was investigated by determining the effect of several life-prolonging antioxidants on the metabolic rate and life span of Drosophila. The respiration rate of groups of continuously agitated flies was determined in a Gilson respirometer. Vitamin E, 2,4-dinitrophenol, nordihydroguaiaretic acid, and thiazolidine carboxylic acid were employed as antioxidants. Results show that all of these antioxidants reduced the oxygen consumption rate and increased the mean life span, and a significant negative linear correlation was found between the mean life span and the metabolic rate. It is concluded that these findings indicate that some antioxidants may inhibit respiration rate in addition to their protective effect against free radical-induced cellular damage.
Document ID
19830063382
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Miquel, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Fleming, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Economos, A. C.
(San Jose State University San Jose, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1982
Publication Information
Publication: Archives of Gerontology and Geriatrics
Volume: 1
ISSN: 0167-4943
Subject Category
Life Sciences (General)
Accession Number
83A44600
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available