NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Sensitivity of bone cell populations to weightlessness and simulated weightlessnessA rat suspension model for simulating certain aspects of weightlessness is discussed. Perturbations in physiological systems induced by this head down suspension model are verified by flight data. Findings of a suppression of osteoblast differentiation help explain the inhibition of bone formation inflight and during Earth-bound simulations. Since the anatomical site for these studies was in the maxilla, which is gravity loaded but non weightbearing in ground-based simulations, the similarity of bone cell kinetic changes, both inflight and in the ground-based model, suggest that fluid shifts rather than unloading may play an important role in bone alterations, at least at this sampling site.
Document ID
19840026080
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Roberts, W. E.
(NASA Ames Research Center Moffett Field, CA, United States)
Morey-Holton, E. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Gonsalves, M. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
July 1, 1984
Publication Information
Publication: ESA The Gravity Relevance in Bone Mineralization Processes
Subject Category
Aerospace Medicine
Accession Number
84N34151
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available