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The effects of immobilization on cortical bone in monkeys (M. nemestrina)Rhesus and pigtail monkeys were restrained for up to seven months in a hypogravic-hypodynamic environment for the purpose of studying the osteoporotic process and its reversibility, particularly in relation to humans. In vivo bending, radiography and tomography are among the techniques that were used. Bone deterioration within one month was detectable only in histological preparation, where resorption and subsequent cavity formation were demonstrated in addition to demineralization of the remaining hard tissue. Norland bone mineral analysis showed the greatest bone demineralization in the proximal tibia (23 percent to 31 percent after six months restraint), recovery did not even necessarily occur after 15 months. The largest bone stiffness decrease was 36 to 40 percent after a six months restraint; normal bending properties but not mineral content were restored after 8-1/2 months. Contrary to earlier studies, it is concluded that bone recovery, though a lengthy process, is possible: cortical bone in the tibia required 40 months.
Document ID
19840041580
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Niklowitz, W. J.
(NASA Ames Research Center Moffett Field, CA, United States)
Bunch, T. E.
(NASA Ames Research Center Moffett Field, CA, United States)
Young, D. R.
(NASA Ames Research Center Moffett Field; San Francisco, University, San Francisco, CA, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1983
Publication Information
Publication: Physiologist, Supplement
Volume: 26
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
84A24367
Distribution Limits
Public
Copyright
Other

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