NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
No effect of sex steroids on compensatory muscle hypertrophyThe effects of orchiectomy and/or subcutaneously implanted testosterone propionate (TP) on the hypertrophic response of rat plantaris muscles to functional overload (induced by bilateral removal of gastrocnemius and soleus muscles) are investigated experimentally. Muscle wet weight, metabolic substrate oxidation, and cytosolic androgen-receptor binding are measured, and the results are presented in tables. Eight weeks after surgery, the plantaris muscle weight as a percentage of body weight is found to be about twice that in rats without muscle overload, regardless of the sex-hormone status. Overloading causes decreased ability to oxidize glucose and pyruvate, decreased succinate dehydrogenase specific activity, and no change in the ability to oxidize beta-hydroxybutyrate or in androgen-receptor binding. The oxidative response is unaffected by orchiectomy or TP or both. It is argued that the actions of sex hormones and functional overload are not synergistic.
Document ID
19840055777
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Max, S. R.
(Maryland Univ. Baltimore, MD, United States)
Rance, N. E.
(Maryland, University Baltimore, MD, United States)
Date Acquired
August 12, 2013
Publication Date
June 1, 1984
Publication Information
Publication: Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
Volume: 56
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
84A38564
Funding Number(s)
CONTRACT_GRANT: NAG2-100
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available