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Nucleic acids, proteins, and chiralityThe present investigation is concerned with experimental results related, in one case, to the chirality of nucleotides, and, in another case, to the possibility of a link between the chirality of nucleic acids, and that of peptides. It has been found that aminoacylation of the 'internal' hydroxyl group of a dinucleoside monophosphate can occur stereoselectively. However, this reaction has not yet been made a part of a working peptide synthesis scheme. The formation and cleavage of oligonucleotides is considered. In the event of the formation of a helical complex between the oligonucleotide and the polymer, 1-prime,5-prime-bonds in the oligomer are found to become more resistant towards cleavage. The conditions required for peptide bond formation are examined, taking into account the known structures of RNA and possible mechanisms for prebiotic peptide bond formation. The possibility is considered that the 2-prime,5-prime-internucleotide linkage could have played an important part in the early days of biological peptide synthesis.
Document ID
19840057708
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Usher, D. A.
(Cornell Univ. Ithaca, NY, United States)
Profy, A. T.
(Cornell Univ. Ithaca, NY, United States)
Walstrum, S. A.
(Cornell Univ. Ithaca, NY, United States)
Needels, M. C.
(Cornell Univ. Ithaca, NY, United States)
Bulack, S. C.
(Cornell Univ. Ithaca, NY, United States)
Lo, K. M.
(Cornell University Ithaca, NY, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1984
Publication Information
Publication: Origins of Life
Volume: 14
Issue: 1-4
ISSN: 0302-1688
Subject Category
Life Sciences (General)
Accession Number
84A40495
Funding Number(s)
CONTRACT_GRANT: NAGW-493
CONTRACT_GRANT: NIH-GM-26249
Distribution Limits
Public
Copyright
Other

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