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Beta-interferon inhibits cell infection by Trypanosoma cruziBeta interferon has been shown to inhibit the capacity of bloodstream forms of the flagellate Trypanosoma cruzi, the causative agent of Chagas' disease, to associate with and infect mouse peritoneal macrophages and rat heart myoblasts. The inhibitory effect was abrogated in the presence of specific antibodies to the interferon. Pretreatment of the parasites with interferon reduced their infectivity for untreated host cells, whereas pretreament of either type of host cell did not affect the interaction. The effect of interferon on the trypanosomes was reversible; the extent of the inhibitory effect was significantly reduced afer 20 min, and was undetectable after 60 min when macrophages were used as host cells. For the myoblasts, 60 min elapsed before the inhibitory effect began to subside and 120 min elapsed before it became insignificant or undetectable.
Document ID
19840062762
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kierszenbaum, F.
(Michigan State University East Lansing, MI, United States)
Sonnenfeld, G.
(Louisville, University Louisville, KY, United States)
Date Acquired
August 12, 2013
Publication Date
February 1, 1984
Publication Information
Publication: Journal of Immunology
Volume: 132
ISSN: 0022-1767
Subject Category
Life Sciences (General)
Accession Number
84A45549
Funding Number(s)
CONTRACT_GRANT: NIH-AI-17041
CONTRACT_GRANT: NIH-AI-14848
CONTRACT_GRANT: NCC2-213
Distribution Limits
Public
Copyright
Other

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