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Acid phosphatase and protease activities in immobilized rat skeletal musclesThe effect of hind-limb immobilization on selected Iysosomal enzyme activities was studied in rat hing-limb muscles composed primarily of type 1. 2A, or 2B fibers. Following immobilization, acid protease and acid phosphatase both exhibited signifcant increases in their activity per unit weight in all three fiber types. Acid phosphatase activity increased at day 14 of immobilization in the three muscles and returned to control levels by day 21. Acid protease activity also changed biphasically, displaying a higher and earlier rise than acid phosphatase. The pattern of change in acid protease, but not acid phosphatase, closely parallels observed muscle wasting. The present data therefore demonstrate enhanced proteolytic capacity of all three fiber types early during muscular atrophy. In addition, the data suggest a dependence of basal hydrolytic and proteolytic activities and their adaptive response to immobilization on muscle fiber composition.
Document ID
19850009200
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Witzmann, F. A.
(Marquette Univ. Milwaukee, WI, United States)
Troup, J. P.
(Marquette Univ. Milwaukee, WI, United States)
Fitts, R. H.
(Marquette Univ. Milwaukee, WI, United States)
Date Acquired
September 5, 2013
Publication Date
April 13, 1982
Subject Category
Life Sciences (General)
Report/Patent Number
NASA-CR-174340
NAS 1.26:174340
Accession Number
85N17509
Funding Number(s)
CONTRACT_GRANT: NIH-AM-00810
CONTRACT_GRANT: NIH-AM-22037
CONTRACT_GRANT: NAS9-15711
Distribution Limits
Public
Copyright
Other

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