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Atrophy and growth failure of rat hindlimb muscles in tail-cast suspensionThe primary objective of the present study is related to an evaluation of a modified tail-cast suspension model as a means of identifying metabolic factors which control or are associated with muscle atrophy and growth failure. Two different control conditions (normal and tail-casted weight bearing) were studied to determine the appropriate control for tail-cast suspension. A description is presented of a model which is most useful for studying atrophy of hindlimb muscles under certain conditions. Female Sprague-Dawley rats were employed in the experiments. Attention is given to growth rate and urinary excretion of urea and ammonia in different types of rats, the relationship between body weight and skeletal muscle weight, and the relationship between animal body weight and rates of protein synthesis and protein degradation.
Document ID
19850032510
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Jaspers, S. R.
(Arizona Univ. Tucson, AZ, United States)
Tischler, M. E.
(Arizona, University Tucson, AZ, United States)
Date Acquired
August 12, 2013
Publication Date
November 1, 1984
Publication Information
Publication: Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
Volume: 57
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
85A14661
Funding Number(s)
CONTRACT_GRANT: NIH-AM-28647
CONTRACT_GRANT: NAGW-227
Distribution Limits
Public
Copyright
Other

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