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Tyrosine administration enhances dopamine synthesis and release in light-activated rat retinaExposure of dark-adapted albino rats to light (350 lux) significantly elevated retinal levels of the dopamine metabolite dihydroxyphenyl acetic acid during the next hour; their return to a dark environment caused dihydroxyphenyl acetic acid levels to fall. Retinal dopamine levels were increased slightly by light exposure, suggesting that the increase in dihydroxyphenyl acetic acid reflected accelerated dopamine synthesis. Administration of tyrosine (100 mg/kg, i.p.) further elevated retinal dihydroxyphenyl acetic acid among light-exposed animals, but failed to affect dopamine release among animals in the dark. These observations show that a physiological stimulus - light exposure - can cause catecholaminergic neurons to become tyrosine-dependent; they also suggest that food consumption may affect neurotransmitter release within the retina.
Document ID
19850042349
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Gibson, C. J.
(University of Western Ontario London Ontario, Canada)
Watkins, C. J.
(Western Ontario, University London, Canada; MIT, Cambridge, MA, United States)
Wurtman, R. J.
(MIT Cambridge, MA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Journal of Neural Transmission
Volume: 56
ISSN: 0300-9564
Subject Category
Life Sciences (General)
Accession Number
85A24500
Funding Number(s)
CONTRACT_GRANT: NGR-22-009-627
CONTRACT_GRANT: NIH-AM-14228
Distribution Limits
Public
Copyright
Other

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