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Alterations in bone forming cells due to reduced weight bearingA reduction in new bone formation occurred as a result of space flight (Cosmos 1129) and in the suspended animal model of Morey-Holton (1979, 1980). The results indicate that alkaline phosphatase activity of the bone-forming cells is also reduced under these conditions, and the cells in the diaphysis are more affected than those in the metaphyseal region. In addition, these cells show (1) reduced proline incorporation into bone matrix, and (2) increased intracellular lysosomal activity. A change in the cytoskeleton could be the common factor in explaining these results. This suggestion is futher supported by the previous observations that colchicine injections result in decreased osteoblastic function.
Document ID
19850065058
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Doty, S. B.
(Columbia, University New York, United States)
Morey-Holton, E.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1984
Publication Information
Publication: Physiologist, Supplement
Volume: 27
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
85A47209
Funding Number(s)
CONTRACT_GRANT: NAGW-238
Distribution Limits
Public
Copyright
Other

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