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Evolution of thiol protective systems in prokaryotesBiological thiols are essential elements in most aspects of cell function but undergo rapid oxidation to disulfides in the presence of oxygen. The evolution of systems to protect against such oxygen toxicity was essential to the emergence of aerobic life. The protection system used by eukaryotes is based upon glutathione (GSH) and GSH-dependent enzymes but many bacteria lack GSH and apparently use other mechanisms. The objective of this research is to elaborate the thiol protective mechanisms employed by prokaryotes of widely divergent evolutionary origin and to understand why GSH became the central thiol employed in essentially all higher organisms. Thiol-selective fluorescent labeling and HPLC analysis has been used to determine key monothiol components.
Document ID
19860017424
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Fahey, R. C.
(California Univ., San Diego La Jolla, CA, United States)
Newton, G. L.
(California Univ., San Diego La Jolla, CA, United States)
Date Acquired
August 12, 2013
Publication Date
May 1, 1986
Publication Information
Publication: NASA, Washington Second Symposium on Chemical Evolution and the Origin and Evolution of Life
Subject Category
Space Biology
Accession Number
86N26896
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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