NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Blood pressure and plasma renin activity as predictors of orthostatic intoleranceThe effect of 3 h standing, followed by a period of head-up tilt (HUT) on physiological response (orthostatic tolerance, blood pressure and heart rate), as well as on plasma vasopressin (PVP) and renin activity (PRA) were studied in 13 dehydrated (to 2.4 pct loss of body weight) subjects. Seven subjects showed signs of orthostatic intolerance (INT), manifested by sweating, pallor, nausea and dizziness. Prior to these symptoms, the INT subjects exhibited lower systolic (SP) and pulse (PP) pressures, and an elevated PRA, compared to the tolerant (TOL) subjects. HUT has aggravated increases of RPA in the INT subjects and caused an increase, higher than in TOL subjects, in PVP, while rehydration has greatly attenuated the PVP response to the HUT and decreased the PRA response. It is concluded that dehydration, together with measurements of SP, PP and PRA, may serve as a means of predicting orthostatic intolerance and may provide a physiological model for studying the causes of intolerance.
Document ID
19860029574
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Harrison, M. H.
(NASA Ames Research Center Moffett Field, CA, United States)
Kravik, S. E.
(NASA Ames Research Center Moffett Field, CA, United States)
Geelen, G.
(NASA Ames Research Center Moffett Field, CA, United States)
Keil, L.
(NASA Ames Research Center Moffett Field, CA, United States)
Greenleaf, J. E.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
November 1, 1985
Publication Information
Publication: Aviation, Space and Environmental Medicine
Volume: 56
ISSN: 0095-6562
Subject Category
Aerospace Medicine
Accession Number
86A14312
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available