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The effect of high energy (HZE) particle radiation (Ar-40) on aging parameters of mouse hippocampus and retinaEight month old C57BL6 mice were exposed (head only) to 0.5 rad or 50 rads of Argon particles at the Lawrence Berkeley Radiation Facility, CA. Neuromotor performance was assessed monthly for six months beginning twelve weeks post-irradiation using a 'string test'. The decline in motor performance was dose-related and none of the animals was able to complete the task after four months of testing. Morphological changes were monitored six and twelve months post-irradiation by light and electron microscopy. The synaptic density in the CA-1 area of the hippocampus decreased six and twelve months after irradiation. The decrease after twelve months was less than after six months. The width of the outer nuclear layer (ONL) of the retina increased with increasing dose. The number of blood vessels between the ONL and the ganglion layer decreased twelve months after irradiation and this area did not show significant accumulation of age pigment.
Document ID
19860032941
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Philpott, D. E.
(NASA Ames Research Center Moffett Field, CA, United States)
Kato, K.
(NASA Ames Research Center Moffett Field, CA, United States)
Corbett, R.
(NASA Ames Research Center Moffett Field, CA, United States)
Stevenson, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Black, S.
(NASA Ames Research Center Moffett Field, CA, United States)
Sapp, W.
(Tuskegee Institute AL, United States)
Miquel, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Lindseth, K. A.
(San Jose State University CA, United States)
Benton, E. V.
(San Francisco, University CA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1985
Publication Information
Publication: Scanning Electron Microscopy
Volume: 3
Subject Category
Life Sciences (General)
Accession Number
86A17679
Distribution Limits
Public
Copyright
Other

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