NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Laser ablation of human atherosclerotic plaque without adjacent tissue injurySeventy samples of human cadaver atherosclerotic aorta were irradiated in vitro using a 308 nm xenon chloride excimer laser. Energy per pulse, pulse duration and frequency were varied. For comparison, 60 segments were also irradiated with an argon ion and an Nd:YAG laser operated in the continuous mode. Tissue was fixed in formalin, sectioned and examined microscopically. The Nd:YAG and argon ion-irradiated tissue exhibited a central crater with irregular edges and concentric zones of thermal and blast injury. In contrast, the excimer laser-irradiated tissue had narrow deep incisions with minimal or no thermal injury. These preliminary experiments indicate that the excimer laser vaporizes tissue in a manner different from that of the continuous wave Nd:YAG or argon ion laser. The sharp incision margins and minimal damage to adjacent normal tissue suggest that the excimer laser is more desirable for general surgical and intravascular uses than are the conventionally used medical lasers.
Document ID
19860037973
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Grundfest, W. S.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Litvack, F.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Forrester, J. S.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Goldenberg, T.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Swan, H. J. C.
(California Institute of Technology, Jet Propulsion Laboratory, Pasadena; Cedars-Sinai Medical Center; California, University Los Angeles, United States)
Date Acquired
August 12, 2013
Publication Date
April 1, 1985
Publication Information
Publication: American College of Cardiology, Journal
Volume: 5
ISSN: 0735-1097
Subject Category
Aerospace Medicine
Accession Number
86A22711
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available