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Immunological analyses of U.S. Space Shuttle crewmembersChanges in the immunoresponsiveness of 'T' lymphocytes following space flight have been reported previously. Additional data collected before and after 11 Shuttle space flights show that absolute lymphocyte numbers, lymphocyte blastogenic capability, and eosinophil percent in the peripheral blood of crewmembers are generally depressed postflight. These responses resemble those associated with physical and emotional stress and may not be related to flight per se. Additional data from Space Shuttle flights 41B and 41D, involving 11 crewmembers, indicate a postflight decrease in cells reacting with 'B' lymphocyte and monocyte monoclonal antibody tags. Further, the loss of 'T' lymphocyte blast capability correlates with the decreased monocyte count (correlation coefficient = 0.697). This finding implies that the previously reported loss of blastogenic capability may be a function of decreased monocyte control, as noted in several nonspaceflight related studies.
Document ID
19860044353
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Taylor, G. R.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Neale, L. S.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Dardano, J. R.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 12, 2013
Publication Date
March 1, 1986
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 57
ISSN: 0095-6562
Subject Category
Aerospace Medicine
Accession Number
86A29091
Distribution Limits
Public
Copyright
Other

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