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Growth and differentiation of mammalian embryonic tissues exposed to hypergravity in vivo and in vitroDecreased cartilage areas in embryonic limbs developing under excess g in vitro, is reported, as well as delayed skeletal development in embryos and fetuses exposed to excess g in utero. 12.5-day mouse limb buds were cultured at 2.6 g, and fixed at two days and six days of culture. In vivo experiments used alizarin-stained 18-day fetuses exposed to 2.3 g. In all studies, cartilage areas were determined using a digitized tablet. Form factor analysis determined that the main effect of in vitro centrifugation was a reduction in length of the limb elements, probably due to the precocious chondrogenesis seen in the upper regions of centrifuged limbs. Similar reductions in length of ossified areas was seen in the in utero studies.
Document ID
19860045662
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Duke, J.
(Texas Univ. Houston, TX, United States)
Janer, L.
(Texas Univ. Houston, TX, United States)
Moore, J.
(Texas, University Houston, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30400
Funding Number(s)
CONTRACT_GRANT: NAG2-332
Distribution Limits
Public
Copyright
Other

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