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Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolismWeightlessness, as experienced during space flight, and simulated weightlessness induce osteopenia. Using the suspended rat model to simulate weightlessness, a reduction in total tibia Ca and bone formation rate at the tibiofibular junction as well as an inhibition of Ca-45 and H-3-proline uptake by bone within 5-7 days of skeletal unloading was observed. Between days 7 and 15 of unloading, uptake of Ca-45 and H-3-proline, and bone formation rate return to normal, although total bone Ca remains abnormally low. To examine the relationship between these characteristic changes in bone metabolism induced by skeletal unloading and vitamin D metabolism, the serum concentrations of 25-hydroxyvitamin D (25-OH-D), 24, 25-dihydroxyvitamin D (24,25(OH)2D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) at various times after skeletal unloading were measured. The effect of chronic infusion of 1,25(OH)2D3 on the bone changes associated with unloading was also determined.
Document ID
19860045687
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Halloran, B. P.
(California Univ. San Francisco, CA, United States)
Bikle, D. D.
(California Univ. San Francisco, CA, United States)
Globus, R. K.
(California Univ. San Francisco, CA, United States)
Levens, M. J.
(California, University San Francisco, United States)
Wronski, T. J.
(Florida, University Gainesville, United States)
Morey-Holton, E.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30425
Distribution Limits
Public
Copyright
Other

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