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Hematologic parameters of astrorats flown on SL-3Hematologic studies were performed on a group of large and small rats which were sacrificed after flying in life sciences shuttle engineering flight SL-3. The results are presented on flight (F) and control (C) 200 gm rats. The small flight animals demonstrated a significant increase in hematocrits, red blood cell counts, hemoglobins and peripheral blood percentages of neutrophils as well as a decrease in percentage of lymphocytes. Erythropoietin (Ep) determinations were similar for the two groups as were the bone marrow an spleen differential counts. In vitro cultures for erythroid colonies of bone marrow showed that in response to different doses of Ep, in all cases where differnces were statistically significant, the F rats had increased colony counts. The changes in red cell parameters could be caused by a decrease in plasma volume. However, no isotopic studies were possible on this flight and this lack points up the need for such studies to determine the red cell mass and plasma volume.
Document ID
19860045720
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Lange, R. D.
(Tennessee Univ. Knoxville, TN, United States)
Andrews, R. B.
(Tennessee Univ. Knoxville, TN, United States)
Gibson, L. A.
(Tennessee Univ. Knoxville, TN, United States)
Wright, P.
(Tennessee Univ. Knoxville, TN, United States)
Dunn, C. D. R.
(Tennessee, University Knoxville, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30458
Distribution Limits
Public
Copyright
Other

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