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Microgravity associated changes in pituitary growth hormone (GH) cells prepared from rats flown on Space Lab 3The effect of microgravity on the release of pituitary growth hormone (GH) in rats is studied. The pituitary glands from six adult rats exposed to microgravity are analyzed for in vitro and in vivo changes in pituitary growth hormone cells. The GH cell functions in the somatotrophs of flight rats are compared to a control group. The two assay procedures employed in the experiment are described. It is observed that intracellular levels of GH are two to three times greater in the flight rats than in the control group; however, the amount of GH released from the somatotrophs is 1.11 + or - 0.4 micrograms for the flight rats and 1.85 + or - 1.3 micrograms for the control rats.
Document ID
19860045721
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hymer, W. C.
(Pennsylvania State Univ. University Park, PA, United States)
Farrington, M.
(Pennsylvania State Univ. University Park, PA, United States)
Hayes, C.
(Pennsylvania State University University Park, United States)
Grindeland, R.
(Pennsylvania State Univ. University Park, PA, United States)
Fast, T.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30459
Funding Number(s)
CONTRACT_GRANT: NASA ORDER A-21991-C
Distribution Limits
Public
Copyright
Other

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