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Morphological and biochemical changes in soleus and extensor digitorum longus muscles of rats orbited in Spacelab 3Muscle atrophy in rats exposed to hypogravity for seven days aboard Spacelab 3 is examined. Hindlimb muscles were harvested 12-16 days postflight, and prepared for enzyme studies and electron microscopy. Simple cell shrinkage was found, with a mean fiber area decrease of 35.8 percent for soleus and 24.9 percent for extensor digitorum longus (EDL) flight muscle fibers, as compared with control muscle fibers. EDL and soleus muscles showed increases in alkaline myofibrillar ATPase, alpha glycerophosphate dehydrogenase, and glycogen, and a decrease in NADH dehydrogenase staining. The 26 percent increase in calcium activated protease suggests that the focal degradation of myofibrils is the key process of myofibril breakdown. The presence in the flight soleus muscles of one percent necrotic fibers is unexplained. The observed shift towards histochemical fast-muscle type properties is consistent with previous findings.
Document ID
19860045726
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Riley, D. A.
(Medical Coll. of Wisconsin Milwaukee, WI, United States)
Slocum, T.
(Medical Coll. of Wisconsin Milwaukee, WI, United States)
Bain, J. L. W.
(Medical Coll. of Wisconsin Milwaukee, WI, United States)
Sedlak, F. R.
(Wisconsin Medical College, Milwaukee, United States)
Elis, S.
(Medical Coll. of Wisconsin Milwaukee, WI, United States)
Satyanarayana, T.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 12, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Physiologist, Supplement
Volume: 28
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
86A30464
Funding Number(s)
CONTRACT_GRANT: NCC2-266
CONTRACT_GRANT: NASA ORDER A-21992-C
CONTRACT_GRANT: NAS2-11305
Distribution Limits
Public
Copyright
Other

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