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Phase shifting two coupled circadian pacemakers - Implications for jet lagTwo Van der Pol oscillators with reciprocal linear velocity coupling are utilized to model the response of the human circadian timing system to abrupt displacements of the environmental time cues (zeitgebers). The core temperature rhythm and sleep-wake cycle simulated by the model are examined. The relationship between the masking of circadian rhythms by environmental variables and behavioral and physiological events and the rates of resynchronization is studied. The effects of zeitgeber phase shifts and zeitgeber strength on the resynchronization rates are analyzed. The influence of intrinsic pacemakers periods and coupling strength on resynchronization are investigated. The simulated data reveal that: resynchronization after a time zone shift depends on the magnitude of the shift; the time of day of the shift has little influence on resynchronization; the strength of zeitgebers affects the rate and direction of the resynchronization; the intrinsic pacemaker periods have a significant effect on resynchronization; and increasing the coupling between the oscillators results in an increase in the rate of resynchronization. The model data are compared to transmeridian flight studies data and similar resynchronization patterns are observed.
Document ID
19860055946
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gander, P. H.
(NASA Ames Research Center Moffett Field, CA, United States)
Kronauer, R. E.
(NASA Ames Research Center Moffett Field, CA, United States)
Graeber, R. C.
(NASA Ames Research Center Moffett Field, CA; Harvard University, Cambridge, MA, United States)
Date Acquired
August 12, 2013
Publication Date
January 1, 1985
Publication Information
Publication: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Issue: 249,
ISSN: 0363-6119
Subject Category
Aerospace Medicine
Accession Number
86A40684
Distribution Limits
Public
Copyright
Other

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