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Protein crystal growth - Growth kinetics for tetragonal lysozyme crystalsResults are reported from theoretical and experimental studies of the growth rate of lysozyme as a function of diffusion in earth-gravity conditions. The investigations were carried out to form a comparison database for future studies of protein crystal growth in the microgravity environment of space. A diffusion-convection model is presented for predicting crystal growth rates in the presence of solutal concentration gradients. Techniques used to grow and monitor the growth of hen egg white lysozyme are detailed. The model calculations and experiment data are employed to discuss the effects of transport and interfacial kinetics in the growth of the crystals, which gradually diminished the free energy in the growth solution. Density gradient-driven convection, caused by presence of the gravity field, was a limiting factor in the growth rate.
Document ID
19870026596
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Pusey, M. L.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Snyder, R. S.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Naumann, R.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Date Acquired
August 13, 2013
Publication Date
May 15, 1986
Publication Information
Publication: Journal of Biological Chemistry
Volume: 261
ISSN: 0021-9258
Subject Category
Materials Processing
Accession Number
87A13870
Distribution Limits
Public
Copyright
Other

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