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Increased response to insulin of glucose metabolism in the 6-day unloaded rat soleus muscleHind leg muscles of female rats were unloaded by tail cast suspension for 6 days. In the fresh-frozen unloaded soleus, the significantly greater concentration of glycogen correlated with a lower activity ratio of glycogen phosphorylase (p less than 0.02). The activity ratio of glycogen synthase also was lower (p less than 0.001), possibly due to the higher concentration of glycogen. In isolated unloaded soleus, insulin (0.1 milliunit/ml) increased the oxidation of D(U-C-14) glucose, release of lactate and pyruvate, incorporation of D-(U-C-14) glucose into glycogen, and the concentration of glucose 6-phosphate more (p less than 0.05) than in the weight-bearing soleus. At physiological doses of insulin, the percent of maximal uptake of 2-deoxy-D-(1,2-H-3) glucose/muscle also was greater in the unloaded soleus. Unloading of the soleus increased, by 50 percent the concentration of insuling receptors, due to no decrease in total receptor number during muscle atrophy. This increase may account for the greater response of glucose metabolism to insulin in this muscle. The extensor digitorum longus, which generally shows little response to unloading, displayed no differential response of glucose metabolism to insulin.
Document ID
19870036167
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Henriksen, Erik J.
(Arizona Univ. Tucson, AZ, United States)
Tischler, Marc E.
(Arizona Univ. Tucson, AZ, United States)
Johnson, David G.
(Arizona, University Tucson, United States)
Date Acquired
August 13, 2013
Publication Date
August 15, 1986
Publication Information
Publication: Journal of Biological Chemistry
Volume: 261
ISSN: 0021-9258
Subject Category
Life Sciences (General)
Accession Number
87A23441
Funding Number(s)
CONTRACT_GRANT: NAGW-227
CONTRACT_GRANT: NAG2-384
Distribution Limits
Public
Copyright
Other

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