Interferon in resistance to bacterial and protozoan infectionsThe effects of genetic differences in mouse strains on the modulation of protozoan infections by interferon (IFN) were investigated. In one set of experiments, three different strains of mice were injected with T. cruzi, and their sera were assayed at five time intervals for IFN titer. A greater quantity of IFN was produced by mouse strains that were susceptible to T. cruzi infection than by the more resistant strain. In another set of experiments, spleen cell cultures from inbred strains of mice were challenged with an antigen made from T.b. rhodesiense. The cells from mice resistant to infection, produced greater amounts of IFN-gamma than did cells from the susceptible mice. In a third set of experiments, it was found that mice injected with T.b. rhodesiense before being infected with a diabetogenic virus (EMC-D) were resistant to the effects of the virus and did not produce virus-specific antibody.
Document ID
19870038921
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Sonnenfeld, Gerald (Louisville Univ. KY, United States)
Gould, Cheryl L. (Louisville Univ. KY, United States)
Kierszenbaum, Felipe (Louisville Univ. KY, United States)
Degee, Antonie L. W. (Louisville Univ. KY, United States)
Mansfield, John M. (Louisville, University KY; Michigan State University, East Lansing; Wisconsin, University, Madison, United States)