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Size and metabolic properties of single muscle fibers in rat soleus after hindlimb suspensionThe effect of 28-day-long hind-limb suspension (HS) combined with 10 daily forceful lengthening contractions of the limb on the morphological and metabolic properties of individual fibers of the soleus was studied in rats, using quantitative histochemical techniques. Compared with nonsuspended controls (CON), soleus wet weights of HS rats were decreased by 49 percent; the fibers staining lightly for myosin ATPase ('light-ATPase' fibers) atrophied more than the 'dark-ATPase' fibers. Single-fiber alpha-glycerophosphate dehydrogenase (GPD) and succinate dehydrogenase (SDH) activities were higher in HS than in CON rats. Daily forceful lengthening contractions did not prevent the HS-induced changes. The results support the view that the soleus fibers can change from a slow-twitch oxidative to a fast-twitch oxidative-glycolytic profile, but rarely to a fast-twitch glycolytic one, and that the SDH and GPD activities per volume of tissue can be increased even when there are severe losses of contractile proteins.
Document ID
19870059299
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hauschka, Edward O.
(California Univ. Los Angeles, CA, United States)
Roy, Roland R.
(California Univ. Los Angeles, CA, United States)
Edgerton, V. Reggie
(California, University Los Angeles, United States)
Date Acquired
August 13, 2013
Publication Date
June 1, 1987
Publication Information
Publication: Journal of Applied Physiology
Volume: 62
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
87A46573
Funding Number(s)
CONTRACT_GRANT: NCA2-IR-390-502
Distribution Limits
Public
Copyright
Other

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