Mechanisms of cell damage in agitated microcarrier tissue culture reactorsCells growing on microcarriers may be damaged by collisions of the microcarrier against another microcarrier or the reactor agitator. Bead-bead collisions are caused by small-scale turbulence, which can also cause high local shear stress on the cells. The cells are also exposed to 10-20 Hz cyclic shear stress by bead rotation.
Document ID
19880023592
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Cherry, Robert S. (Rice Univ. Houston, TX, United States)
Papoutsakis, E. Terry (Rice University Houston, TX, United States)