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Disuse atrophy, plasma corticosterone, and muscle glucocorticoid receptor levelsThe effect of whole-body suspension on the time course and the extent of plasma corticosterone changes and the tissue sensitivity to glucocorticoids were investigated in rats subjected to seven days of whole-body suspension. Plasma corticosterone increased significantly on the first and the third days of suspension, but returned to control levels by day seven. Muscle glucocorticoid receptors exhibited a characteristic hormonal specificity (evaluated in competitive-displacement experiments). In controls, receptor site concentration in the slow-twitch soleus was comparable to that in the fast-twitch gastrocnemius and plantaris, but was significantly less than in the extensor; seven days of suspension resulted in significant differential effects on muscle receptor levels. The largest increase in receptor concentration was observed in the soleus in which it remained elevated after the receptor levels in other muscles returned to normal.
Document ID
19880028119
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Steffen, J. M.
(Louisville Univ. KY, United States)
Musacchia, X. J.
(Louisville, University KY, United States)
Date Acquired
August 13, 2013
Publication Date
October 1, 1987
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 58
ISSN: 0095-6562
Subject Category
Life Sciences (General)
Accession Number
88A15346
Funding Number(s)
CONTRACT_GRANT: NSG-2325
CONTRACT_GRANT: NAGW-70
Distribution Limits
Public
Copyright
Other

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