NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Development and characterization of Histoplasma capsulatum-reactive murine T-cell lines and clonesSeveral Histoplasma capsulatum-reactive murine cloned T-cell lines (TCLs) were isolated from spleens of C57BL/6 mice immunized with viable H. capsulatum yeast cells, using the methodology of Kimoto and Fathman (1980). These T-cells were characterized phenotypically as Thy-1.2(+) Lyt-1(+) L3T4(+) Lyt-2(-), that is, as the helper/inducer phenotype. The cloned T cells proliferate in response to histoplasmin and, in some cases, to heterologous fungal anigens. Upon injection of mice with the antigen, the T-cells mediate local delayed-type hypersensitivity responses and, after stimulation, release regulatory lymphokines.
Document ID
19880033040
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Deepe, George S., Jr.
(Cincinnati Univ. OH, United States)
Smith, James G.
(Cincinnati Univ. OH, United States)
Denman, David
(Cincinnati Univ. OH, United States)
Bullock, Ward E.
(Cincinnati, University OH, United States)
Sonnenfeld, Gerald
(Louisville, University KY, United States)
Date Acquired
August 13, 2013
Publication Date
December 1, 1986
Publication Information
Publication: Infection and Immunity
Volume: 54
ISSN: 0019-9567
Subject Category
Life Sciences (General)
Accession Number
88A20267
Funding Number(s)
CONTRACT_GRANT: NIH-AI-23017
CONTRACT_GRANT: NCC2-213
CONTRACT_GRANT: NIH-AI-17339
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available