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Role of 5-hydroxytryptamine in the regulation of brain neuropeptides in normal and diabetic ratThe effect of 5-hydroxytryptamine (5-HT) alteration on brain dopamine (DA), norepinephrine (NE), beta-endorphin (beta-E), and immunoreactive insulin was studied in Sprague-Dawley diabetic and control rats. Diabetes was induced using alloxan (45 mg/kg), 15 days prior to sacrificing. Both control and diabetic animals were treated with either p-chlorophenylalanine (PCPA, 300 mg/kg) three days prior to sacrificing or fluoxetine (10 mg/kg) twice daily for three days. PCPA treatment significantly decreased brain content of 5-HT and 5-hydroxyindolel acetic acid, while it caused significant increase and decrease in brain beta-E and insulin levels, respectively, in both normal and diabetic rat. Meanwhile, the administration of fluoxetine resulted in significant increase in brain content of 5-HT, DA, NE and insulin but significant decline of beta-E in diabetic and saline control rats. The results of this experiment indicate that 5-HT may be regulating both beta-E and insulin regardless of the availability of pancreatic insulin.
Document ID
19880039248
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kolta, Malak G.
(Auburn Univ. AL, United States)
Williams, Byron B.
(Auburn University AL, United States)
Soliman, Karam F. A.
(Florida Agricultural and Mechanical University Tallahassee, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1986
Publication Information
Publication: Hormone Research
Volume: 23
ISSN: 0301-0163
Subject Category
Life Sciences (General)
Accession Number
88A26475
Funding Number(s)
CONTRACT_GRANT: NSG-2183
CONTRACT_GRANT: NIH-RR-0811
Distribution Limits
Public
Copyright
Other

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