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Life sciences, biotechnology, and microgravityGrowth hormone (GH) studies on rats flown aboard Spacelab 3 are discussed, and evidence for the direct effect of microgravity on cell function is reviewed. SL-3 rat GH cells were found to experience a secretory lesion (they contained more hormone per cell, but released less per cell relative to controls). Pituitary cell culture experiments on the STS-8 mission showed that GH cells did not subsequently release as much hormone as did control cells, indicating a secretory lesion. Changes in bone and muscle noted in SL-3 rats are related to GH cell findings.
Document ID
19880047909
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Hymer, W. C.
(Pennsylvania State Univ. University Park, PA, United States)
Hayes, C.
(Pennsylvania State University University Park, United States)
Grindeland, R.
(NASA Ames Research Center Moffett Field, CA, United States)
Lanhan, J. W.
(McDonnell Douglas Astronautics Co. Saint Louis, MO, United States)
Morrison, D.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1987
Subject Category
Life Sciences (General)
Report/Patent Number
AAS PAPER 86-464
Meeting Information
Meeting: Aerospace century XXI: Space sciences, applications, and commercial developments
Location: Boulder, CO
Country: United States
Start Date: October 26, 1986
End Date: October 29, 1986
Sponsors: AAS
Accession Number
88A35136
Funding Number(s)
CONTRACT_GRANT: NAS9-17416
CONTRACT_GRANT: NASA ORDER A-21991-C
CONTRACT_GRANT: NAS9-15565
CONTRACT_GRANT: NCC2-370
Distribution Limits
Public
Copyright
Other

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