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Does vector-free gravity simulate microgravity? Functional and morphologic attributes of clinorotated nerve and muscle grown in cell cultureCocultured Xenopus neurons and myocytes were subjected to nonvectorial gravity by clinostat rotation to determine the effects of microgravity on cell development and communications. Observed effects included increases in the myocyte and its nuclear area, fragmentation of nucleoli, the appearance of neuritic aneurysms, decreased growth in the presence of trophic factors, and decreased yolk utilization. These effects were most notable at 1-10 rpm and depended on the onset and duration of rotation. It is found that, in microgravity, cell differentiation is altered by interference with cytoskeleton-related mechanisms. It is suggested that the alteration of the distribution of acetylcholine receptor aggregates on myocytes which occurs might indicate that microgravity affects brain development.
Document ID
19880066799
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gruener, Raphael
(Arizona Univ. Tucson, AZ, United States)
Hoeger, Glenn
(Arizona, University Tucson, United States)
Date Acquired
August 13, 2013
Publication Date
February 1, 1988
Publication Information
Publication: Physiologist, Supplement
Volume: 31
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
88A54026
Funding Number(s)
CONTRACT_GRANT: NAG2-326
Distribution Limits
Public
Copyright
Other

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