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Role of glucocorticoids in increased muscle glutamine production in starvationThe role of glucocorticoids in the synthesis of muscle glutamine during starvation was investigated in adrenalectomized fasted rats injected with cortisol (1 mg/100 g body weight). It was found that administration of cortisol in vivo increased (compared to nontreated starved adrenalectomized controls) the glutamine/glutamate ratio and the activity of glutamine synthetase in the diaphragm and the extensor digitorum muscles, and that these effects were abolished by prior treatment with actinomycin D or proflavine. The results obtained in in vitro experiments, using fresh-frozen soleus, extensor digitorum longus, and diaphragm muscle preparations, supported the in vivo indications of the cortisol-enhanced glutamine synthesis and protein turnover in starved adrenalectomized animals.
Document ID
19890025383
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Tischler, Marc E.
(Arizona Univ. Tucson, AZ, United States)
Henriksen, Erik J.
(Arizona Univ. Tucson, AZ, United States)
Cook, Paul H.
(Arizona, University Tucson, United States)
Date Acquired
August 13, 2013
Publication Date
July 1, 1988
Publication Information
Publication: Muscle and Nerve
Volume: 11
ISSN: 0148-639X
Subject Category
Life Sciences (General)
Accession Number
89A12754
Funding Number(s)
CONTRACT_GRANT: NAG2-384
CONTRACT_GRANT: NAGW-227
Distribution Limits
Public
Copyright
Other

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