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Effects of immobilization on rat hind limb muscles under non-weight-bearing conditionsThe effect of stretched and unstretched immobilization of a hind limb on the concentration and the metabolism of proteins in the hind-limb muscles of rats was investigated. The animals were divided into three groups: (1) weight-bearing controls, (2) tail-cast-suspended, and (3) suspended, with one hind limb immobilized with the ankle in dorsiflexion (30-40 deg angle) and the other freely moving. It was found that unloading the hind limbs for 6 days by tail cast suspension caused soleus to atrophy and reduced growth of the gastrocnemius and plantaris muscles; unloading resulted in a higher degradation rate and lower synthesis rate in both in vitro and in vivo. Chronic stretch of the unloaded soleus not only prevented its atrophy but led to significant hypertrophy, relative to weight-bearing controls, with increases in both the sarcoplasmic and myofibrillar protein fractions. Immobilizing one ankle in dorsiflexion prevented the inhibition of growth in the plantaris and gastrocnemius muscles due to unloading.
Document ID
19890025384
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Jaspers, Stephen R.
(Massachusetts, University Worcester, United States)
Fagan, Julie M.
(Rutgers University New Brunswick, NJ, United States)
Satarug, Soisungwan
(Massachusetts Univ. Worcester, MA, United States)
Cook, Paul H.
(Massachusetts Univ. Worcester, MA, United States)
Tischler, Marc E.
(Arizona, University Tucson, United States)
Date Acquired
August 13, 2013
Publication Date
May 1, 1988
Publication Information
Publication: Muscle and Nerve
Volume: 11
ISSN: 0148-639X
Subject Category
Life Sciences (General)
Accession Number
89A12755
Funding Number(s)
CONTRACT_GRANT: NIH-AM-28647
CONTRACT_GRANT: NAGW-227
CONTRACT_GRANT: NAG2-384
Distribution Limits
Public
Copyright
Other

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