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Regulation of protein degradation in muscle by calciumCalcium-dependent regulation of intracellular protein degradation was studied in isolated rat skeletal muscles incubated in vitro in the presence of a large variety of agents known to affect calcium movement and distribution. The effect of different classes of protease inhibitors was tested to determine the responsible proteolytic systems involved in calcium-dependent degradation. The results suggest that nonlysosomal leupetin- and E-64-c-sensitive proteases are resposible for calcium-dependent proteolysis in muscle.
Document ID
19890029160
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Zeman, Richard J.
(State Univ. of New York Brooklyn, NY, United States)
Kameyama, Tsuneo
(State Univ. of New York Brooklyn, NY, United States)
Matsumoto, Kazue
(State Univ. of New York Brooklyn, NY, United States)
Bernstein, Paul
(State Univ. of New York Brooklyn, NY, United States)
Etlinger, Joseph D.
(New York, State University Brooklyn, United States)
Date Acquired
August 14, 2013
Publication Date
November 5, 1985
Publication Information
Publication: Journal of Biological Chemistry
Volume: 260
ISSN: 0021-9258
Subject Category
Life Sciences (General)
Accession Number
89A16531
Funding Number(s)
CONTRACT_GRANT: NIH-5-R01-HL-21970
CONTRACT_GRANT: NAG2-162
CONTRACT_GRANT: NIH-HL-31494
Distribution Limits
Public
Copyright
Other

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