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The stimulation of arachidonic acid metabolism in human platelets by hydrodynamic stressesThe effects of stimulating human platelets by thrombin and by hydrodynamic stresses on the platelets' arachidonic acid metabolism were investigated using (1-C-14)-arachidonic acid label and a specially designed viscometer that ensured laminar shear flow with a nearly uniform shear rate throughout the flow region. It was found that platelets activated by thrombin formed principally thromboxane A2, 12-hydroxy 5,8,10-heptadecatrienoic acid and 12-hydroxy 5,8,10,14-eicosatetraenoic acid (12-HETE). On the other hand, platelets activated by shear, formed only 12-HETE (although arachidonic acid metabolism was stimulated); no cyclooxygenase metabolites were detected. Results indicate that platelets may greatly increase their 12-HETE production when activated by passage through a high-stress region of the circulation, such as an atherosclerotic stenosis.
Document ID
19890032469
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Rajagopalan, Sridhar
(Rice Univ. Houston, TX, United States)
Mcintire, Larry V.
(Rice University Houston, TX, United States)
Hall, Elizabeth R.
(Rice Univ. Houston, TX, United States)
Wu, Kenneth K.
(Texas, University Houston, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1988
Publication Information
Publication: Biochimica et Biophysica Acta
Volume: 958
ISSN: 0005-2760
Subject Category
Life Sciences (General)
Accession Number
89A19840
Funding Number(s)
CONTRACT_GRANT: NIH-P01-NS-23327
CONTRACT_GRANT: NIH-HL-17437
CONTRACT_GRANT: NIH-1-R01-HL-18672
CONTRACT_GRANT: NAG9-207
Distribution Limits
Public
Copyright
Other

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