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Decreased swelling pressure of rat nucleus pulposus associated with simulated weightlessnessData are presented on the effects of actual and simulated weightlessness on the swelling pressure of nucleus pulposus in rats exposed to 12.5 days of flight aboard Cosmos 1887 or to seven days of tail suspension, respectively. The flight-exposed rats were adapted to normal gravity for over 50 hrs prior to sacrifice and tissue harvesting. In the experiments with flight-exposed rats, swelling pressures were 690, 675, and 622 mm Hg for flight rats, synchronous controls, and vivarium controls, respectively. In experiments with simulated weightlessness, swelling pressures were 295, 610, and 527 mm Hg for tail-suspended rats, cage controls, and vivarium controls, respectively, suggesting that fluid moves into the disc during seven days of simulated weightlessness.
Document ID
19900028430
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hargens, Alan R.
(NASA Ames Research Center Moffett Field, CA, United States)
Mahmood, Mubashar
(NASA Ames Research Center Moffett Field; California, University, La Jolla, United States)
Date Acquired
August 14, 2013
Publication Date
February 1, 1989
Publication Information
Publication: Physiologist, Supplement
Volume: 32
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
90A15485
Distribution Limits
Public
Copyright
Other

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