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Polymerization of the cyclic pyrophosphates of nucleosides and their analoguesWhen 2-prime-deoxythymidine 3-prime, 5-prime-cyclic diphosphate, or the cyclic pyrophosphates of the acyclic nucleoside analogs II and IV are heated to 65-85 C in the presence of imidazole, oligomers with lengths up to 20-30 are formed in excellent yield. This reaction provides a useful source of oligomers for use as templates in aqueous condensation reactions. In the absence of evidence to the contrary, it is assumed that the oligomers are atactic. The potential significance of this reaction in prebiotic chemistry is discussed.
Document ID
19900040577
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Tohidi, Mahrokh
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, Leslie E.
(Salk Institute for Biological Studies San Diego, CA, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1990
Publication Information
Publication: Journal of Molecular Evolution
Issue: 30 1
ISSN: 0022-2844
Subject Category
Chemistry And Materials (General)
Accession Number
90A27632
Funding Number(s)
CONTRACT_GRANT: NAGW-1660
Distribution Limits
Public
Copyright
Other

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