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Polymerization of amino acids containing nucleotide basesThe nucleoamino acids 1-(3'-amino,3'-carboxypropyl)uracil (3) and 9-(3'-amino,3'-carboxypropyl)adenine (4) have been prepared as (L)-en-antiomers and as racemic mixtures. When 3 or 4 is suspended in water and treated with N,N'-carbon-yldiimidazole, peptides are formed in good yield. The products formed from the (L)-enantiomers are hydrolyzed to the monomeric amino acids by pronase. Attempts to improve the efficiency of these oligomerizations by including a polyuridylate template in the reaction mixture were not successful. Similarly, oligomers derived from the (L)-enantiomer of 3 did not act as templates to facilitate the oligomerization of 4.
Document ID
19900053070
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Ben Cheikh, Azzouz
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, Leslie E.
(Salk Institute for Biological Studies San Diego, CA, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1990
Publication Information
Publication: Journal of Molecular Evolution
Volume: 30
ISSN: 0022-2844
Subject Category
Chemistry And Materials (General)
Accession Number
90A40125
Funding Number(s)
CONTRACT_GRANT: NAGW-1660
Distribution Limits
Public
Copyright
Other

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