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Environmental Control Of A Genetic ProcessE. coli bacteria altered to contain DNA sequence encoding production of hemoglobin made to produce hemoglobin at rates decreasing with increases in concentration of oxygen in culture media. Represents amplification of part of method described in "Cloned Hemoglobin Genes Enhance Growth Of Cells" (NPO-17517). Manipulation of promoter/regulator DNA sequences opens promising new subfield of recombinant-DNA technology for environmental control of expression of selected DNA sequences. New recombinant-DNA fusion gene products, expression vectors, and nucleotide-base sequences will emerge. Likely applications include such aerobic processes as manufacture of cloned proteins and synthesis of metabolites, production of chemicals by fermentation, enzymatic degradation, treatment of wastes, brewing, and variety of oxidative chemical reactions.
Document ID
19910000031
Acquisition Source
Legacy CDMS
Document Type
Other - NASA Tech Brief
Authors
Khosla, Chaitan
(Caltech)
Bailey, James E.
(Caltech)
Date Acquired
August 14, 2013
Publication Date
January 1, 1991
Publication Information
Publication: NASA Tech Briefs
Volume: 15
Issue: 1
ISSN: 0145-319X
Subject Category
Life Sciences
Report/Patent Number
NPO-17576
Accession Number
91B10031
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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