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Radiation biology of HZE particlesThe biological effects of heavy charged particle (HZE) radiation are of particular interest to travellers and planners for long duration space flights where exposure levels represent a potential health hazard. The unique feature of HZE radiation is the structured pattern of its energy deposition in targets which may be related to charge, velocity, or rate of energy loss. There are many consequences of this feature to biological endpoints when compared to effects of ionizing photons. Dose vs response and dose rate kinetics are modified, DNA and cellular repair systems are altered in their abilities to cope with damage and, the qualitative features of damage are unique for different ions. These features must be incorporated into any risk assessment system for radiation health management. HZE induced mutation, cell inactivation and altered organogenesis will be discussed emphasizing studies with the nematode Caenorhabditis elegans and cultured cells. Observations from radiobiology experiments in space will also be reviewed along with plans for future space-based studies.
Document ID
19910029449
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Nelson, Gregory A.
(JPL Pasadena, CA, United States)
Date Acquired
August 14, 2013
Publication Date
October 1, 1990
Subject Category
Life Sciences (General)
Report/Patent Number
IAF PAPER 90-548
Accession Number
91A14072
Distribution Limits
Public
Copyright
Other

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