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Atrial natriuretic factor increases vascular permeabilityAn increase in central blood volume in microgravity may result in increased plasma levels of atrial natriuretic factor (ANF). In this study, it was determined whether ANF increases capillary permeability to plasma protein. Conscious, bilaterally nephrectomized male rats were infused with either saline, ANF + saline, or hexamethonium + saline over 2 h following bolus injections of (I-125)-albumin and (C-14)-dextran of similar molecular size. Blood pressure was monitored, and serial determinations of hematocrits were made. Animals infused with 1.0 microg/kg per min ANF had significantly higher hematocrits than animals infused with saline vehicle. Infusion of ANF increased the extravasation of (I-125)-albumin, but not (C-14)-dextran from the intravascular compartment. ANF also induced a depressor response in rats, but the change in blood pressure did not account for changes in capillary permeability to albumin; similar depressor responses induced by hexamethonium were not accompanied by increased extravasation of albumin from the intravascular compartment. ANF may decrease plasma volume by increasing permeability to albumin, and this effect of ANF may account for some of the signs and symptoms of space motion sickness.
Document ID
19910033268
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Lockette, Warren
(Wayne State Univ. Detroit, MI, United States)
Brennaman, Bruce
(Wayne State University, Detroit; USVA, Medical Center Allen Park; Henry Ford Hospital, Detroit; Michigan, University, Ann Arbor, United States)
Date Acquired
August 15, 2013
Publication Date
December 1, 1990
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 61
ISSN: 0095-6562
Subject Category
Life Sciences (General)
Accession Number
91A17891
Distribution Limits
Public
Copyright
Other

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