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Cardiopulmonary responses to acute hypoxia, head-down tilt and fluid loading in anesthetized dogsCardiopulmonary responses to acute hypoxia (HY), fluid loading by saline infusion (FL), and head-down tilt (HD) of mechanically ventilated anesthetized dogs were investigated by measuring thermodynamics and pulmonary gas exchange. It was found that HD decreased the total respiratory compliance both during HY and normoxia (NO) and that the reduction in compliance by FL was twice as large as by HD. Superimposing HD on HY doubled the increase in vascular resistance due to HY alone. In the systemic circulation, HD lowered the resistance to below NO levels. There was a significant positive correlation between the changes in blood volume and in pulmonary artery pressure for experimental transitions, suggesting that a shift in blood volume from systemic to pulmonary circulations and changes in the total blood volume may contribute substantially to these apparent changes in resistance.
Document ID
19920033330
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Loeppky, J. A.
(Lovelace Foundation for Medical Education and Research Albuquerque, NM, United States)
Scotto, P.
(Lovelace Foundation for Medical Education and Research Albuquerque, NM, United States)
Riedel, C.
(Lovelace Foundation for Medical Education and Research Albuquerque, NM, United States)
Avasthi, P.
(Lovelace Foundation for Medical Education and Research Albuquerque, NM, United States)
Koshukosky, V.
(Lovelace Foundation for Medical Education and Research Albuquerque, NM, United States)
Chick, T. W.
(Lovelace Medical Foundation Albuquerque, NM, United States)
Date Acquired
August 15, 2013
Publication Date
December 1, 1991
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 62
ISSN: 0095-6562
Subject Category
Life Sciences (General)
Accession Number
92A15954
Funding Number(s)
CONTRACT_GRANT: NAG9-375
Distribution Limits
Public
Copyright
Other

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