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Vector-averaged gravity alters myocyte and neuron properties in cell cultureThe effect of changes in the gravitational field of developing neurons and myocytes on the development of these cells was investigated using observations of rotated cultures of embryonic spinal neurons and myocytes in a horizontal clinostat, in which rotation produces, from the cells' perspective, a 'vector-free' gravity environment by continous averaging of the vector, thus simulating the microgravity of space. It was found that, at rotation rates between 1 and 50 rpm, cellular and nuclear areas of myocytes become significantly enlarged and the number of presumptive nucleoli increase; in neurons, frequent and large swellings appeared along neuritic shafts. Some of these changes were reversible after the cessation of rotation.
Document ID
19920033333
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gruener, Raphael
(Arizona Univ. Tucson, AZ, United States)
Hoeger, Glenn
(Arizona, University Tucson, United States)
Date Acquired
August 15, 2013
Publication Date
December 1, 1991
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 62
ISSN: 0095-6562
Subject Category
Life Sciences (General)
Accession Number
92A15957
Funding Number(s)
CONTRACT_GRANT: NAGW-539
CONTRACT_GRANT: NAGW-1705
Distribution Limits
Public
Copyright
Other

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