Protein crystal growth in spaceStudies of protein crystal growth in the microgravity environment in space are described with special attention given to the crystal growth facilities and the techniques used in Space Shuttle experiments. The properties of large space-grown crystals of gamma interferon, elastase, lathyros ochrus lectin I, and few other proteins grown on various STS flights are described. A comparison of the microgravity-grown crystals with the bast earth-grown crystals demonstrated that the space-grown crystals are more highly ordered at the molecular level than their earth-grown counterparts. When crystallization conditions were optimized, the microgravity-grown protein crystals were larger, displayed more uniform morphologies, and yielded diffraction data to significantly higher resolution than their earth-grown counterparts.
Document ID
19920051574
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Delucas, Lawrence J. (NASA Marshall Space Flight Center Huntsville, AL, United States)
Bugg, Charles E. (Alabama, University Birmingham, United States)