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Estimation of the initial equilibrium constants in the formation of tetragonal lysozyme nucleiResults are presented from a study of the equilibria, kinetic rates, and the aggregation pathway which leads from a lysozyme monomer crystal to a tetragonal crystal, using dialyzed and recrystallized commercial hen eggwhite lysozyme. Relative light scattering intensity measurements were used to estimate the initial equilibrium constants for undersaturated lysozyme solutions in the tetragonal regime. The K1 value was estimated to be (1-3) x 10 exp 4 L/mol. Estimates of subsequent equilibrium constants depend on the crystal aggregation model chosen or determined. Experimental data suggest that tetragonal lysozyme crystal grows by addition of aggregates preformed in the bulk solution, rather than by monomer addition.
Document ID
19920053243
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Pusey, Marc L.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1991
Publication Information
Publication: Journal of Crystal Growth
Volume: 110
ISSN: 0022-0248
Subject Category
Materials Processing
Accession Number
92A35867
Distribution Limits
Public
Copyright
Other

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