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Adaptations of young adult rat cortical bone to 14 days of spaceflightTo determine whether mature humeral cortical bone would be modified significantly by an acute exposure to weightlessness, adult rats (110 days old) were subjected to 14 days of microgravity on the COSMOS 2044 biosatellite. There were no significant changes in peak force, stiffness, energy to failure, and displacement at failure in the flight rats compared with ground-based controls. Concentrations and contents of hydroxyproline, calcium, and mature stable hydroxylysylpyridinoline and lysylpyridinoline collagen cross-links remained unchanged after spaceflight. Bone lengths, cortical and endosteal areas, and regionl thicknesses showed no significant differences between flight animals and ground controls. The findings suggest that responsiveness of cortical bone to microgravity is less pronounced in adult rats than in previous spaceflight experiments in which young growing animals were used. It is hypothesized that 14 days of spaceflight may not be sufficient to impact the biochemical and biomechanical properties of cortical bone in the mature rat skeleton.
Document ID
19920068847
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Vailas, A. C.
(NASA Ames Research Center Moffett Field, CA, United States)
Vanderby, R., Jr.
(NASA Ames Research Center Moffett Field, CA, United States)
Martinez, D. A.
(NASA Ames Research Center Moffett Field, CA, United States)
Ashman, R. B.
(NASA Ames Research Center Moffett Field, CA, United States)
Ulm, M. J.
(NASA Ames Research Center Moffett Field, CA, United States)
Grindeland, R. E.
(NASA Ames Research Center Moffett Field, CA, United States)
Durnova, G. N.
(NASA Ames Research Center Moffett Field, CA, United States)
Kaplanskii, A.
(Wisconsin, University, Madison; NASA, Ames Research Center Moffett Field, CA; Texas Scottish Rite Hospital, Dallas; Institute of Biomedical Problems, Moscow, Russia)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
92A51471
Funding Number(s)
CONTRACT_GRANT: NGT-70093
CONTRACT_GRANT: NAG2-568
Distribution Limits
Public
Copyright
Other

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