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Preosteoblast production in Cosmos 2044 rats - Short-term recovery of osteogenic potentialThe influence of a 13.8-day spaceflight and about 8.5-11 h of recovery at 1 g on fibro blastlike osteoblast precursor cells was assessed in the periodontal ligament of rat maxillary first molars. Preosteoblasts (C + D cells), less differentiated progenitor cells (A + A prime cells), and nonosteogenic fibroblastlike cells (B cells) were identified by nuclear volume analysis. No differences were observed among flight, synchronous vivarium, and basal control groups in the A + A prime or C + D cell compartments. Compared with previous spaceflight experiments, the present data are consistent with a postflight response to replinish preosteoblasts and restore periodontal ligament osteogenic potential. These data emphasize the need to unequivocally determine the flight effect by killing the animals in-flight and further assess the postflight recovery phenomenon.
Document ID
19920068849
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Garetto, Lawrence P.
(NASA Ames Research Center Moffett Field, CA, United States)
Morey, Emily R.
(NASA Ames Research Center Moffett Field, CA, United States)
Durnova, G. N.
(NASA Ames Research Center Moffett Field, CA, United States)
Kaplanskii, A. S.
(NASA Ames Research Center Moffett Field, CA, United States)
Roberts, W. E.
(Indiana, University, Indianapolis; NASA, Ames Research Center Moffett Field, CA; Institute of Biomedical Problems, Moscow, Russia)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
92A51473
Funding Number(s)
CONTRACT_GRANT: NIH-DE-09237-01
CONTRACT_GRANT: NCC2-594
Distribution Limits
Public
Copyright
Other

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